•ModelMuse does not currently support parameter estimation of models that employ local grid-refinement such as MODFLOW-LGR (Mehl and Hill, 2013).
•ModelMuse does not currently support parameter estimation of PHAST (Parkhurst and others, 2004), MT3DMS (Zheng and Wang, 1999), MT3D-USGS (Bedekar and others, 2016), or MODPATH (Pollock, 2016) models.
•ModelMuse was not specifically designed to support the use of PEST++ (White and others, 2020). However, the PEST control file generated by ModelMuse can be used with PEST++ with some modifications.
1.On line 5 of the PEST control file, the "noobsreref" option along with the comment on the rest of the line must be removed.
2.In the observation groups section of the PEST control file, the names of any covariance files must be deleted.
•ModelMuse can only import MODFLOW-2005 and MODFLOW-NWT models even though it can be used for parameter estimation for other MODFLOW-2005 based models such as MODFLOW-OWHM (Hanson and others, 2015).
