State Water Resources Research Institute Program


Project ID: 2012MD285B
Title: Multixenobiotic resistance (MXR) induction in amphipods (Hyalella azteca) by agricultural ditch sediment and water (Graduate Fellowship)
Project Type: Research
Start Date: 3/01/2012
End Date: 2/28/2013
Congressional District: MD 5
Focus Categories: Toxic Substances, Agriculture
Keywords: ecotoxicology, non-target effects, agricultural ditches, risk assessment
Principal Investigators: Kearney, Philip (Maryland); Lamp, William
Federal Funds: $ 6,000
Non-Federal Matching Funds: $ 12,240
Abstract: Pesticides are common in agriculture and may enter aquatic systems from surrounding crop fields. This study will determine the effect of contaminated sediment and water from agricultural ditches on the multixenobiotic resistance (MXR) response in a model amphipod species. Sediment and water will be used to induce MXR and the production of P-glycoprotein (P-gp), which transports exogenous toxins out of cells. The response will be visualized using rhodamine B (RB) dye and a spectrophotometer. A lower concentration of P-gp in exposed amphipods compared to control amphipods is expected in response to certain contaminants in the sediment and water. This bioassay based on the MXR response would serve as an indicator that certain field-applied pesticides are entering the surrounding aquatic environments.

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